When you run a Job on an interactive cluster in Talend Studio, you can basically run any workload. Interactive clusters are created for an undetermined duration, but you can manually terminate and restart them if needed. Multiple users can share such clusters to do collaborative and interactive analytics.
When you run a Job on a transient cluster in Talend Studio, you process the Job faster and the cluster automatically shuts down and when processing is finished for a lower cost of usage. Transient clusters are created according to your Spark configuration and you cannot restart them once shut down.